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Rethinking the development of Ebola treatments

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The Lancet Global Health

September 25, 2014

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In response to the current outbreak, the international community has endorsed the clinical use of unregistered treatments for Ebola. Even with this accelerated pathway to in-human testing and use, radically novel approaches to drug development will be needed to improve the likelihood that a treatment is realised. Bypassing steps in development does not alter the probability of success, and historical patterns in drug development suggest that there is a slim probability of success with the current portfolio of potential Ebola treatments (all of which are were in preclinical development prior to the outbreak)....

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