Mark Holodniy

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Mark Holodniy, MD, FACP, FIDSA

  • Professor of Medicine, Stanford University School of Medicine
  • Stanford Health Policy Associate

Office of Public Health Surveillance & Research
VA Palo Alto Health Care System
3801 Miranda Ave. (132)
Palo Alto, California 94304-5107

(650) 852-3408 (voice)
(650) 858-3978 (fax)


Dr. Holodniy is Professor of Medicine (Infectious Diseases & Geographic Medicine) at Stanford University and has been a full time employee of the Department of Veterans Affairs (VA) for over 25 years. He has been national director of Public Health Surveillance and Research (PHSR) in VA since 1999, which is a national program office based at the VA Palo Alto Health Care System (VAPAHCS). His current VA responsibilities include public health surveillance, conducting outbreak and large-scale lookback investigations within VA, and directing the VA Public Health Reference Laboratory (PHRL). PHRL is a national VA laboratory, aligned with CDC and the Laboratory Response Network (LRN), which supports clinical care and public health investigations utilizing state-of-the-art diagnostic microbiology methods and equipment. He also serves as the hospital epidemiologist and staff infectious disease physician for the VAPAHCS. Previously, he directed pharmacy services at the VAPAHCS from 1996-1999, the HIV clinical program at VAPAHCS from 1991-2011, and was the acting director of the VA Cooperative Studies Program Coordinating Center at VAPAHCS from 2007-2009, where he oversaw a portfolio of several multicenter VA studies and the VA DNA Bank Genomics Program.

His research program focuses on viral evolution, microbial development of drug resistance, clinical trial evaluation of novel diagnostics and antimicrobial compounds, and evaluation of clinical outcomes associated with infectious diseases. In that capacity, Dr. Holodniy has overseen the conduct of over 80 clinical and diagnostic assay trials at VAPAHCS since 1991. He has also mentored many infectious disease fellows, graduate students, and Epidemic Intelligence Service (EIS) officers, in collaboration with CDC.