Although gastric hypochlorhydria is a risk factor for gastroenteritis and for gastric cancer, no reliable, inexpensive, noninvasive test exists for screening or epidemiologic studies. We aimed to evaluate the sensitivity and specificity of the blood quininium resin test (bQRT) for hypochlorhydria, against pH monitoring. Twelve fasting adult volunteers-seven with and five without H. pylori infection-ingested 80 mg/kg of quininium resin twice, once with and once without acid suppression. Gastric pH was monitored for 75 minutes; serum samples were obtained at times 0 and 75 minutes. The bQRT levels were compared to gastric pH, controlling for omeprazole use and H. pylori infection. Subjects with a median recorded pH > or =3.5 were considered hypochlorhydric. Using a bQRT level of 10 as a cutoff for hypochlorhydria, the sensitivity and specificity of the bQRT were 100% and 37.5%, respectively. The bQRT predicted omeprazole use more accurately than pH monitoring. In conclusions, The bQRT has a high sensitivity for hypochlorhydria, making it potentially useful in populations with a high prevalence of hypochlorhydria. In its current formulation, the bQRT's low specificity makes it less useful in low-risk population.

Background: While trauma systems improve the outcome of injury in children, there is a paucity of information regarding trauma regionalization system function amid dramatic changes in the financial structure of health care.

Objective: To describe the distribution of acute hospitalization of children with severe trauma by level of hospital trauma care designation in California.

Methods: Retrospective observational study of a population-based cohort from 1998 to 2004. The California Office of Statewide Health Planning and Development (OSHPD) patient Discharge Data Set 1998-2004 was used. Patients were included if: age 0-19 years, trauma International Classification of Diseases, 9th Edition (ICD-9) diagnostic codes, and e-codes (n = 127,841). Differential rates of hospitalization in trauma-designated hospitals vs. non-trauma-designated hospitals were calculated for death and injury severity score. Injury severity scores (ISSs) were calculated from ICD-9 codes. Primary outcomes were hospitalization in a trauma center and death.

Results: From 1998 to 2004, 55%-60% of children 0-14 years and 55%-70% of children 15-19 years with trauma requiring hospitalization were discharged from trauma-designated hospitals. Children with severe injury were consistently hospitalized in trauma-designated hospitals (70%-78%) at a rate higher than children with moderate (60%-70%) and mild (50%-60%) injury. Trends for hospitalization in trauma-designated hospitals increased over the time span of the study (p 0.05). Approximately 20% of hospitalized children who died (I = 1,426) died 2 or more days after injury in non-trauma-designated hospitals.

Conclusions: A majority of children with trauma were cared for in trauma-designated hospitals over the study period. However, 20% of children with severe injuries and 20% of pediatric deaths greater than 2 days after injury were cared for in non-trauma-designated hospitals. Further investigation is warranted in order to enhance clinical protocols and policies that ensure access to appropriate regional trauma care for all children in need.

Objective: Despite evidence and recommendations encouraging the delivery of high-risk newborns in hospitals with subspecialty or high-level NICUs, increasing numbers are being delivered in other facilities. Causes for this are unknown. We sought to explore the impact of diffusion of specialty or midlevel NICUs on the types of hospitals in which low birth weight newborns are born.

Design: We used birth certificate, death certificate, and hospital discharge data for essentially all low birth weight, singleton California newborns born between 1993 and 2000. We identified areas likely to have been affected by the opening of a new nearby midlevel unit, analyzed changes over time in the share of births that took place in midlevel NICU hospitals, and compared patterns in areas that were and were not likely affected by the opening of a new midlevel unit. We also tracked the corresponding changes in the share of births in high-level hospitals and in those without NICU facilities (low-level).

Results: The probability of a 500- to 1499-g infant being born in a midlevel unit increased by 17 percentage points after the opening of a new nearby unit. More than three quarters of this increase was accounted for by reductions in the probability of birth in a hospital with a high-level unit (15 points), and the other portion was resulting from reductions in the share of newborns delivered in hospitals with low-level centers (2 points). Similar patterns were observed in 1500- to 2499-g newborns.

Conclusions: The introduction of new midlevel units was associated with significant shifts of births from both high-level and low-level hospitals to midlevel hospitals. In areas in which new midlevel units opened, the majority of the increase in midlevel deliveries was attributable to shifts from high-level unit births. Continued proliferation of midlevel units should be carefully assessed.

We investigated the determinants of inpatient rehabilitation costs in the Department of Veterans Affairs (VA) and examined the relationship between length of stay (LOS) and discharge costs using data from VA and community rehabilitation hospitals. We estimated regression models to identify patient characteristics associated with specialized inpatient rehabilitation costs. VA data included 3,535 patients discharged from 63 facilities in fiscal year 2001. We compared VA costs to community rehabilitation hospitals using a sample from the Uniform Data System for Medical Rehabilitation of 190,112 patients discharged in 1999 from 697 facilities. LOS was a strong predictor of cost for VA and non-VA hospitals. Functional status, measured by Functional Independence Measure (FIM) scores at admission, was statistically significant but added little explanatory value after controlling for LOS. Although FIM scores were associated with LOS, FIM scores accounted for little variance in cost after controlling for LOS. These results are most applicable to researchers conducting cost-effectiveness analyses.

This issue of CHP/PCOR's quarterly newsletter, which covers news from the summer 2006 quarter, includes articles about:

• research by CHP/PCOR investigators that influenced the Centers for Disease Control and Prevention to recommend widespread voluntary HIV screening for all Americans ages 13 to 64 -- a significant change from the CDC's previous HIV screening guidelines;
• a CHP/PCOR study on patient safety culture in U.S. hospitals -- the largest effort to date to measure hospitals' safety culture and seek to improve it through an intervention that gets hospital executives out of their offices and on to the hospital floors;
• an early-stage project in which CHP/PCOR is collaborating with the Center on Democracy, Development and the Rule of Law to study the relationship between health interventions, governance and development;
• an evidence report examining the challenges of diagnosing and treating anthrax in children, prepared by the Stanford-UCSF Evidence-based Practice Center; and
• a study by CHP/PCOR fellow Kate Bundorf which found that depending on the definition of "affordability" that is used, health insurance is "affordable" to between one-quarter and three-quarters of the uninsured -- and many of those who can't afford insurance purchase it anyway.

During the 2001 US anthrax attacks, mortality from inhalational anthrax was significantly lower than had been reported historically, which was attributed in part to early identification and timely treatment. During future attacks, clinicians will rely on published descriptions of the clinical features of inhalational anthrax to rapidly diagnose patients and institute appropriate treatment. Published descriptions of typical inhalation anthrax usually include patients presenting with cough, dyspnea, or chest pain and found to have abnormal lung examination results with pleural effusions or enlarged mediastinum.

The purpose of this article is to evaluate whether atypical presentations of inhalational anthrax occur and to describe the features of these presentations. We define atypical presentations as those in patients with confirmed anthrax infection who do not have known cutaneous, gastrointestinal, or inhalational ports of entry. We reviewed the case reports of 42 patients with atypical anthrax (published between 1900 and 2004) that may have had an inhalational source of infection to evaluate whether their clinical presentations differed from the typical findings of inhalational anthrax. Patients with atypical anthrax were less likely to have cough, chest pain, or abnormal lung examination results than patients with typical inhalational anthrax (P.05 for all comparisons). A previously published screening protocol for patients with suspected anthrax correctly identified 91% of patients with atypical presentations.

We conclude that although uncommon, atypical presentations of inhalational anthrax likely occur. Timely diagnosis and treatment of patients with inhalational anthrax require clinical awareness of the full spectrum of signs and symptoms associated with inhalational anthrax.

Objective:

To describe an academic medical center's experience with housestaff involvement in the implementation of a new clinical information system, with particular emphasis on resident contributions in tailoring the technology to meet the workflow needs of the center.

Methods:

A resident advisory group was formed to tailor the new system. Housestaff developed user interface screens to streamline presentation of patient data. Order sets were developed, offering an opportunity for education in standardized care and "best practice." A rounds report displays aggregated patient specific data for use in prerounding and rapid assessment of patient information. A sign-out tool was designed to facilitate transfer of information during change of shift.

Results:

Residents contributed in tailoring the technology to meet the workflow needs of our academic medical center setting.

Conclusion:

The design and implementation of a new clinical information system can be used to introduce concepts important in practice-based learning and systems-based practice.

Many states have "prudent layperson" mandates that require health plans to reimburse hospitals for emergency department (ED) care delivered to patients who believe that they have symptoms warranting emergency treatment. Increased, and possibly unnecessary, ED use has often been attributed to these policies. We use data from thirty-five states to study relationships between passage of prudent layperson policies in the late 1990s and ED use among the privately insured. None of the analyses show evidence that the mandates are associated with increased use. We conclude that prudent layperson mandates are not associated with increases in ED visits among privately insured patients.