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We present a methodology and database mediator tool for integrating modern knowledge-based systems, such as the Stanford EON architecture for automated guideline-based decision-support, with legacy databases, such as the Veterans Health Information Systems & Technology Architecture (VISTA) systems, which are used nation-wide. Specifically, we discuss designs for database integration in ATHENA, a system for hypertension care based on EON, at the VA Palo Alto Health Care System. We describe a new database mediator that affords the EON system both physical and logical data independence from the legacy VA database. We found that to achieve our design goals, the mediator requires two separate mapping levels and must itself involve a knowledge-based component.

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Proceedings of the 1999 Annual Meeting of the American Medical Informatics Association
Authors
Mary K. Goldstein
Mark A. Musen
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Agency for Health Care Policy and Research EPCTM Evidence Report/Technology Assessment No. 10. (Prepared by UCSF-Stanford Evidence-based Practice Center under contract #290-97-0013)
Authors
Paul A. Heidenreich
Mark A. Hlatky
Number
AHCPR Publication No. 00-E003 (report) and No. 00-E002 (summary).
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This preliminary report analyzes the spread of health technology in 16 nations with widely divergent health care systems, using treatment of heart attacks as a case study.

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Health Affairs
Authors
Daniel P. Kessler
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For this report, the Technology Evaluation Center, an AHCPR Evidence-based Practice Center of the Blue Cross and Blue Shield Association, conducted a systematic review of the evidence from randomized controlled trials on the relative effectiveness of alternative strategies for androgen suppression as treatment of advanced prostate cancer.

Prostate cancer is a disease of older men, and is second only to lung cancer in cancer mortality for men. For 1998, it was estimated that 184,500 new cases of prostate cancer would be diagnosed, and 39,200 men would die of prostate cancer that year.

In 1994, the total Medicare expenditure for treatment of prostate cancer was $1,411,687,900. Of the total, $477,851,000 was for androgen suppression therapy using luteinizing hormone-releasing hormone (LHRH) agonists. The prevalence of prostate cancer, and the expenditures for its treatment, are likely to increase with the aging of the population and the trend to earlier detection of the disease.

Three key issues are addressed in the report:

  • The relative effectiveness of the available methods for monotherapy (orchiectomy, LHRH agonists, and antiandrogens).
  • The effectiveness of combined androgen blockade compared to monotherapy.
  • The effectiveness of immediate compared to deferred androgen suppression.
  • Two supplementary analyses were also conducted for each key question:

  • Meta-analysis of overall survival at 2 or 5 years (as permitted by the data).
  • Cost-effectiveness analysis.
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    Evidence Report/Technology Assessment No. 4. (Prepared by Blue Cross/Blue Shield Association Evidence-based Practice Center under Contract NO. 290-97-0015). AHCPR Publication # 99-EE0012. Rockville, Maryland: Agency for Health Care Policy and Researc
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    AHCPR Publication No. 99-EE0012.
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    A growing body of evidence suggests that managed care can reduce overall health care costs but provides little insight into how this could happen. One possibility is that managed care influences the adoption of new medical technologies. In examining the relationship between health maintenance organization (HMO) activity and market-level availability and use of magnetic resonance imaging (MRI), we find that high HMO market share is associated with low levels of MRI availability and use. This suggests that managed care may be able to reduce health care costs by influencing the adoption and use of new medical equipment and technologies.

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    Health Affairs
    Authors
    Laurence C. Baker
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