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Mark A. Hlatky
Journal Articles

Association of Adverse Pregnancy Outcomes With Risk of Atherosclerotic Cardiovascular Disease in Postmenopausal Women

Mark A. Hlatky, Marcia Stefanick
JAMA Cardiology , 2020

Cardiovascular disease is the leading cause of death among women in the U.S. and identification of sex-specific risk factors could enhance cardiovascular risk assessment and prevention. Pregnancy is an exposure unique to women: 85% of women give birth at least once in their lives, and up to 30% may experience an adverse pregnancy outcome (APO).

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Journal Articles

PCSK9 Inhibitors Economics and Policy

Mark A. Hlatky, Dhruv S. Kazi
Journal of the American College of Cardiology , 2017

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors substantially reduce low-density lipoprotein cholesterol, but it is presently unclear whether they also reduce mortality. The list prices of PCSK9 inhibitors in the United States (>$14,500 per year) are >100× higher than generic statins, and only a small fraction of their higher cost is likely to be recovered by prevention of cardiovascular events.

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Journal Articles

Cost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL

James V. Freeman, David W. Hutton, Geoffrey D. Barnes, Ruo P. Zhu, Douglas K. Owens, Alan M. Garber, Alan S. Go, Mark A. Hlatky, Paul A. Heidenreich, Paul J. Wang, Amin Al-Ahmad, Mintu P. Turakhia
Circulation: Arrhythmia and Electrophysiology , 2016

Background—Randomized trials of left atrial appendage (LAA) closure with the Watchman device have shown varying results, and its cost effectiveness compared with anticoagulation has not been evaluated using all available contemporary trial data.

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Journal Articles

Quality of Life and Economic Outcomes of Assessing Fractional Flow Reserve With Computed Tomography Angiography

Mark A. Hltaky, Bernard De Bruyne, Gianluca Pontone, Manesh R. Patel, Bjarne L. Norgaard, Robert A. Byrne, Nick Curzen, Ian Purcell, Matthias Gutberlet, Gilles Rioufol, Ulrich Hink, Herwig Walter Schuchlenz, Gudrun Feuchtner, Martine Gilard, Daniele Andreini, Jesper M. Jensen, Martin Hadamitzky, Alan Wilk, Furong Wang, Campbell Rogers, Pamela S. Douglas
Journal of the American College of Cardiology , 2015

Evaluating patients who may have coronary artery disease (CAD) is a challenging and extensive process. With an array of testing options and possible results, finding a method that is accurate, cost-effective, and as uninvasive as possible helps patients achieve a higher quality of life during the testing process.

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Journal Articles

Cost-Effectiveness of Adding Cardiac Resynchronization Therapy to an Implantable Cardioverter-Defibrillator Among Patients With Mild Heart Failure

Christopher Y. Woo, Erika J. Strandberg, Michelle D. Schmiegelow, Allison L. Pitt, Mark A. Hlatky, Douglas K. Owens, Jeremy D. Goldhaber-Fiebert
2015

new study by Stanford researchers indicates adding cardiac resynchronization therapy to an implanted cardioverter-defibr

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Journal Articles

Risk of Cardiovascular Events Associated With Current Exposure to HIV Antiretroviral Therapies in a US Veteran Population

Manisha Desai, Vilija Joyce, Eran Bendavid, Richard A. Olshen, Mark A. Hlatky, Adam Chow, Mark Holodniy, Paul Barnett, Douglas K. Owens
Clinical Infectious Diseases , 2015

Background. To characterize the association of antiretroviral drug combinations on risk of cardiovascular events.

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Journal Articles

Association of coronary CT angiography or stress testing with subsequent utilization and spending among medicare beneficiaries

Shreibati, J.B., Laurence Baker, Mark Hlatky
JAMA - Journal of the American Medical Association , 2011
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Journal Articles

Cost Effectiveness of Genetic Eesting in Family Members of Patients with Long QT Syndrome

Marco V. Perez, Narmadan A. Kumarasamy, Douglas K. Owens, Paul J Wang, Mark Hlatky
Circulation: Cardiovascular Quality and Outcomes , 2010

Background— Family members of patients with established long-QT syndrome (LQTS) often lack definitive clinical findings, yet may have inherited an LQTS mutation and be at risk of sudden death. Genetic testing can identify mutations in 75% of patients with LQTS, but genetic testing of family members remains controversial.

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Journal Articles

Cost-Effectiveness of Using High-Sensitivity C-Reactive Protein to Identify Intermediate- and Low-Cardiovascular-Risk Individuals for Statin Therapy

Lee KK, Cipriano LE, Douglas K. Owens, Go AS, Mark Hlatky
Circulation , 2010

BACKGROUND: -Many myocardial infarctions and strokes occur in individuals with low-density lipoprotein cholesterol levels below recommended treatment thresholds. High sensitivity C-reactive protein (hs-CRP) testing has been advocated to identify low- and intermediate-risk individuals who may benefit from statin therapy. Methods and Results-A decision analytic Markov model was used to follow hypothetical cohorts of individuals with normal lipid levels but without coronary artery disease, peripheral arterial disease, or diabetes mellitus.

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Journal Articles

Repeat Coronary Revascularization Procedures after Successful Bare-Metal or Drug-Eluting Stent Implantations

Cynthia A. Yock, Isbill JM, King SB, Mark Hlatky
Journal of Invasive Cardiology , 2010
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Journal Articles

CABG versus PCI for multivessel coronary artery disease - authors' reply

Mark A. Hlatky, Dena M. Bravata, Kathryn M. McDonald, Douglas Owens
The Lancet , 2009
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Working Papers

A Randomized Trial of Therapies for Type 2 Diabetes and Coronary Artery Disease

(The BARI 2D Study Group), Robert L. Frye, Phyllis August, Maria Mori Brooks, Regina M. Hardison, Sheryl F. Kelsey, Joan M. MacGregor, Trevor J. Orchard, Bernard R. Chaitman, Saul M. Genuth, Suzanne H. Goldberg, Mark A. Hlatky, Teresa L.Z. Jones, Mark E. Molitch, Richard W. Nesto, Edward Y. Sako, Burton E. Sobel
New England Journal of Medicine , 2009

Background Optimal treatment for patients with both type 2 diabetes mellitus and stable ischemic heart disease has not been established.

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Journal Articles

The Year in Epidemiology, Health Services Research, and Outcomes Research

Mark A. Hlatky, Paul A. Heidenreich
Journal of the American College of Cardiology , 2009

There have been many new developments in the broad fields of epidemiology, health services research (HSR), and outcomes research during the past year, many more than can be discussed in detail in this review. We selected articles published since the last article in this series, covering roughly the period April 2007 through March 2008, that examined important issues or advanced research methods in the field.

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Journal Articles

Coronary Artery Bypass Surgery Compared with Percutaneous Coronary Interventions for Multivessel Disease: A Collaborative Analysis of Individual Patient Data from Ten Randomised Trials

Mark A. Hlatky, Boothroyd DB, Dena M. Bravata, Boersma E, Booth J, Brooks MM, Carrie MD, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kahler J, Kelsey SF, King SB, Kosinski AS, Lopes N, Kathryn M. McDonald, Rodriguez A, Serruys P, Sigwart P, Stables RH, Douglas K. Owens, Pocock SJ
The Lancet , 2009

Background

Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease. Although the procedures have been compared in several randomised trials, their long-term effects on mortality in key clinical subgroups are uncertain. We undertook a collaborative analysis of data from randomised trials to assess whether the effects of the procedures on mortality are modified by patient characteristics.

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Journal Articles

Isolated disease of the proximal left anterior descending artery. comparing the effectiveness of percutaneous coronary interventions and coronary artery bypass surgery

John R. Kapoor, Allison L. Gienger, Reza Ardehali, Robin Varghese, Marco V. Perez, Vandana Sundaram, Kathryn M. McDonald, Douglas K. Owens, Mark A. Hlatky, Dena Bravata
JACC: Cardiovascular Interventions , 2008

Objectives: This study sought to systematically compare the effectiveness of percutaneous coronary intervention and coronary artery bypass surgery in patients with single-vessel disease of the proximal left anterior descending (LAD) coronary artery.

Background: It is uncertain whether percutaneous coronary interventions (PCI) or coronary artery bypass grafting (CABG) surgery provides better clinical outcomes among patients with single-vessel disease of the proximal LAD.

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Journal Articles

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE Study.

Assimes TL, Knowles JW, Basu A, Iribarren C, Southwick A, Tang H, Ashber D, Li J, Fair JM, Rubin GD, Sidney S Sidney S, Stephen P. Fortmann, Go AS, Mark A. Hlatky, Myers RM, Risch N, Quertermous T
Human Molecular Genetics , 2008

A susceptibility locus for coronary artery disease (CAD) at chromosome 9p21 has recently been reported, which may influence the age of onset of CAD. We sought to replicate these findings among white subjects and to examine whether these results are consistent with other racial/ethnic groups by genotyping three single nucleotide polymorphisms (SNPs) in the risk interval in the Atherosclerotic Disease, Vascular Function, and Genetic Epidemiology (ADVANCE) study. One or more of these SNPs was associated with clinical CAD in whites, U.S. Hispanics and U.S. East Asians.

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Journal Articles

Incidental Pulmonary Nodules on Cardiac Computed Tomography: Prognosis and Use

Iraberren C, Mark A. Hlatky, Chandra M, Fair JM, Rubin GD, Go AS, Burt JR, Stephen P. Fortmann
American Journal of Medicine , 2008

BACKGROUND: Small asymptomatic lung nodules are found frequently in the course of cardiac computed tomography (CT) scanning. However, the utility of assessing and reporting incidental findings in healthy, asymptomatic subjects is unknown.

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Journal Articles

Common Polymorphisms of ALOX5 and ALOX5AP and Risk of Coronary Artery Disease

Assimes TL, Knowles JW, Priest JR, Basu A, Volcik KA, Southwick A, Tabor HK, Hartiala J, Allayee H, Grove ML, Tabibiazar R, Sidney S, Stephen P. Fortmann, Go A, Mark A. Hlatky, Iribarren C, Boerwinkle E, Myers R, Risch N, Quertermous T
Human Genetics , 2008

Recent human genetic studies suggest that allelic variants of leukotriene pathway genes influence the risk of clinical and subclinical atherosclerosis. We sequenced the promoter, exonic, and splice site regions of ALOX5 and ALOX5AP and then genotyped 7 SNPs in ALOX5 and 6 SNPs in ALOX5AP in 1,552 cases with clinically significant coronary artery disease (CAD) and 1,583 controls from Kaiser Permanente including a subset of participants of the coronary artery risk development in young adults study. A nominally significant association

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Journal Articles

Systematic Review: The Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Graft Surgery

Dena M. Bravata, Allison Gienger, Kathryn M. McDonald, Vandana Sundaram, MV Perez, R Varghese, JR Kapoor, R Ardehali, Douglas K. Owens, Mark A. Hlatky
Annals of Internal Medicine , 2007

Background: The comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) for patients in whom both procedures are feasible remains poorly understood.

Purpose: To compare the effectiveness of PCI and CABG in patients for whom coronary revascularization is clinically indicated.

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Journal Articles

Rosiglitazone Increased Heart failure But Did Not Differ from Metformin Plus Sulfonylurea for Other CV Outcomes at Interim Analysis

Mark A. Hlatky, Dena M. Bravata
American College of Physicians Journal Club , 2007
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Journal Articles

Systematic Review: The Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Surgery

Dena M. Bravata, Allison Gienger, Kathryn M. McDonald, Vandana Sundaram, MV Perez, R Varghese, JR Kapoor, R Ardehali, Douglas K. Owens, Mark A. Hlatky
Annals of Internal Medicine , 2007

Background: The comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) for patients in whom both procedures are feasible remains poorly understood.

Purpose: To compare the effectiveness of PCI and CABG in patients for whom coronary revascularization is clinically indicated.

Data Sources: MEDLINE, EMBASE, and Cochrane databases (1966-2006); conference proceedings; and bibliographies of retrieved articles.

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Journal Articles

Statin and Beta-Blocker Therapy and the Initial Presentation of Coronary Heart Disease

A Go, C Iribarren, M Chandra, PV Lathon, Stephen P. Fortmann, T Quertermous, Mark Hlatky
Annals of Internal Medicine , 2006

Background:

Coronary atherosclerosis develops slowly over decades but is frequently characterized clinically by sudden unstable episodes. Patients who present with unstable coronary disease, such as acute myocardial infarction, may systematically differ from patients who present with relatively stable coronary disease, such as exertional angina.

Objective:

To examine whether medication use or patient characteristics influence the mode of initial clinical presentation of coronary disease.

Design:

Case-control study.

Setting:

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Journal Articles

Cost-Effectiveness of Implantable Cardioverter-Defibrillators

Gillian D. Sanders, Mark A. Hlatky, Douglas K. Owens
New England Journal of Medicine , 2005

Background:

Eight randomized trials have evaluated whether the prophylactic use of an implantable cardioverter-defibrillator (ICD) improves survival among patients who are at risk for sudden death due to left ventricular systolic dysfunction but who have not had a life-threatening ventricular arrhythmia. We assessed the cost-effectiveness of the ICD in the populations represented in these primary-prevention trials.

Methods:

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Journal Articles

Evidence-based medicine and policy: the case of the implantable cardioverter defibrillator

Mark A. Hlatky, Gillian D. Sanders, Douglas K. Owens
Health Affairs , 2005

The implantable cardioverter defibrillator (ICD) is a costly new treatment for patients at high risk of sudden cardiac death. Randomized trials of the ICD showed it to be effective in some groups of patients but not in others. While new trials testing the ICD were ongoing to clarify the evidence, policymakers faced immediate decisions about providing insurance coverage for the device.

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Journal Articles

Health-related quality of life in patients with pulmonary arterial hypertension

Mary K. Goldstein, Shafazand S, Doyle RL, Mark A. Hlatky, Michael K. Gould
Chest , 2004

STUDY OBJECTIVES: Patients with pulmonary arterial hypertension (PAH) often present with dyspnea and severe functional limitations, but their health-related quality of life (HRQOL) has not been studied extensively. This study describes HRQOL in a cohort of patients with PAH.

DESIGN: Cross-sectional study.

SETTING: A tertiary care, university hospital-based, pulmonary hypertension (PH) clinic.

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