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Margaret L. Brandeau
Journal Articles

Cost-Effectiveness of HIV Preexposure Prophylaxis for People Who Inject Drugs in the United States

Cora L. Bernard, Margaret L. Brandeau, Keith Humphreys, Eran Bendavid, Mark Holodniy, Christopher Weyant, Douglas K. Owens, Jeremy Goldhaber-Fiebert
Annals of Internal Medicine , 2016

Background: The total population health benefits and costs of HIV preexposure prophylaxis (PrEP) for people who inject drugs (PWID) in the United States are unclear.

Objective: To evaluate the cost-effectiveness and optimal delivery conditions of PrEP for PWID.

Design: Empirically calibrated dynamic compartmental model.

Data Sources: Published literature and expert opinion.

Target Population: Adult U.S. PWID.

Time Horizon: 20 years and lifetime.

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Journal Articles

Evaluating Cost-effectiveness of Interventions That Affect Fertility and Childbearing: How Health Effects Are Measured Matters

Jeremy Goldhaber-Fiebert, Margaret Brandeau
Medical Decision Making , 2015

BACKGROUND: Current guidelines for economic evaluations of health interventions define relevant outcomes as those accruing to individuals receiving interventions. Little consensus exists on counting health impacts on current and future fertility and childbearing. Our objective was to characterize current practices for counting such health outcomes.

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Journal Articles

Modeling and Calibration for Exposure to Time-Varying, Modifiable Risk Factors: The Example of Smoking Behavior in India

Jeremy Goldhaber-Fiebert, Margaret L. Brandeau
Medical Decision Making , 2015

BACKGROUND:

Risk factors increase the incidence and severity of chronic disease. To examine future trends and develop policies addressing chronic diseases, it is important to capture the relationship between exposure and disease development, which is challenging given limited data.

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Journal Articles

Are organic foods safer or healthier than conventional alternatives? A systematic review.

Crystal Smith-Spangler, Margaret L. Brandeau, Hunter, G.E., Clay Bavinger, Pearson, M., Eschbach, P.J., Vandana Sundaram, Hau Liu, Schirmer, P., Stave, C., Ingram Olkin, Dena M. Bravata
Annals of Internal Medicine , 2012
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Journal Articles

Balancing immunological benefits and cardiovascular risks of antiretroviral therapy: When is immediate treatment optimal?

Negoescu, D.M., Douglas K. Owens, Margaret L. Brandeau, Eran Bendavid
Clinical Infectious Diseases , 2012
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Journal Articles

Optimal link removal for epidemic mitigation: A two-way partitioning approach

Eva Enns, Mounzer, J.J., Margaret Brandeau
Mathematical Biosciences , 2012
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Journal Articles

Effectiveness and Cost Effectiveness of Expanding Harm Reduction Programs and HIV Antiretroviral Therapy in a Mixed HIV epidemic: An Analysis for Ukraine

Sabina S. Alistar, Douglas Owens, Margaret Brandeau
PLoS Med , 2011

Background Injection drug use (IDU) and heterosexual virus transmission both contribute to the growing mixed HIV epidemics in Eastern Europe and Central Asia. In Ukraine—chosen in this study as a representative country—IDU-related risk behaviors cause half of new infections, but few injection drug users (IDUs) receive methadone substitution therapy. Only 10% of eligible individuals receive antiretroviral therapy (ART). The appropriate resource allocation between these programs has not been studied.

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Journal Articles

The cost-effectiveness and population outcomes of expanded HIV screening and antiretroviral treatment in the united states

Long, E. F., Margaret Brandeau, Douglas Owens
Annals of Internal Medicine, , 2010

Abstract

BACKGROUND:

Although recent guidelines call for expanded routine screening for HIV, resources for antiretroviral therapy (ART) are limited, and all eligible persons are not currently receiving treatment.

OBJECTIVE:

To evaluate the effects on the U.S. HIV epidemic of expanded ART, HIV screening, or interventions to reduce risk behavior.

DESIGN:

Dynamic mathematical model of HIV transmission and disease progression and cost-effectiveness analysis.

DATA SOURCES:

Published literature.

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Journal Articles

Cost-effectiveness of strategies for diagnosing pulmonary embolism among emergency department patients presenting with undifferentiated symptoms

Duriseti, R. S., Margaret Brandeau
Annals of Emergency Medicine , 2010

Abstract

STUDY OBJECTIVE:

Symptoms associated with pulmonary embolism can be nonspecific and similar to many competing diagnoses, leading to excessive costly testing and treatment, as well as missed diagnoses. Objective studies are essential for diagnosis. This study evaluates the cost-effectiveness of different diagnostic strategies in an emergency department (ED) for patients presenting with undifferentiated symptoms suggestive of pulmonary embolism.

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Journal Articles

Cost effectiveness of nationwide Hepatitis B catch-up vaccination among children and adolescents in China

Hutton DW, So SK, Margaret Brandeau
Hepatology , 2010

Liver disease and liver cancer associated with childhood-acquired chronic hepatitis B are
leading causes of death among adults in China. Despite expanded newborn hepatitis B

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Journal Articles

Cost-effective control of chronic viral diseases: Finding the optimal level of screening and contact tracing

Armbruster B, Margaret Brandeau
Mathematical Biosciences , 2010

Chronic viral diseases such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV) afflict millions of people worldwide. A key public health challenge in managing such diseases is identifying infected, asymptomatic individuals so that they can receive antiviral treatment. Such treatment can benefit both the treated individual (by improving quality and length of life) and the population as a whole (through reduced transmission).

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Journal Articles

The Cost Effectiveness and Population Outcomes of Expanded HIV Screening and Antiretroviral Treatment in the United States

Elisa F. Long, Margaret Brandeau, Douglas Owens
Annals of Internal Medicine , 2010

Background: Although recent guidelines call for expanded routine screening for HIV, resources for antiretroviral therapy (ART) are limited, and all eligible persons are not currently receiving treatment.

Objective: To evaluate the effects on the U.S. HIV epidemic of expanded ART, HIV screening, or interventions to reduce risk behavior.

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Journal Articles

Comparative Effectiveness of HIV Testing and Treatment in Highly Endemic Regions

Eran Bendavid, Margaret L. Brandeau, Wood R, Douglas K. Owens
Archives of Internal Medicine , 2010

BACKGROUND: Universal testing and treatment holds promise for reducing the burden of human immunodeficiency virus (HIV) in sub-Saharan Africa, but linkage from testing to treatment sites and retention in care are inadequate.

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Journal Articles

Optimal Investment in HIV Prevention Programs: More Is Not Always Better

Margaret L. Brandeau, Gregory S. Zaric
Health Care Management Science , 2009

This paper develops a mathematical/economic framework to address the following question: Given a particular population, a specific HIV prevention program and a fixed amount of funds that could be invested in the program, how much money should be invested?

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Journal Articles

Potential Population Health Outcomes and Expenditures of HIV Vaccination Strategies in the United States

Long EF, Margaret Brandeau, Douglas Owens
Vaccine , 2009

Estimating the potential health benefits and expenditures of a partially effective HIV vaccine is an important consideration in the debate about whether HIV vaccine research should continue. We developed an epidemic model to estimate HIV prevalence, new infections, and the cost-effectiveness of vaccination strategies in the U.S. Vaccines with modest efficacy could prevent 300,000-700,000 HIV infections and save $30 billion in healthcare expenditures over 20 years. Targeted vaccination of high-risk individuals is economically efficient, but

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Policy Briefs

Recommendations for Modeling Disaster Responses in Public Health and Medicine: A Position Paper of the Society for Medical Decision Making

Margaret L. Brandeau, McCoy JH, Hupert H, Jon-Erik Holty, Dena Bravata
Medical Decision Making , 2009

Purpose. Mathematical and simulation models are increasingly used to plan for and evaluate health sector responses to disasters, yet no clear consensus exists regarding best practices for the design, conduct, and reporting of such models. The authors examined a large selection of published health sector disaster response models to generate a set of best practice guidelines for such models.

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