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Julie Parsonnet
Journal Articles

Cost-Effectiveness of a Potential Prophylactic Helicobacter pylori Vaccine in the United States.

Rupnow MF, Chang AH, Ross D. Shachter, Douglas Owens, Julie Parsonnet
Journal of Infectious Disease , 2009

Background. Helicobacter pylori vaccines are under development to prevent infection. We quantified the cost‐effectiveness of such a vaccine in the United States, using a dynamic transmission model.

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Journal Articles

Investigation of Mediastinitis Due to Coagulase-Negative Staphylococci After Cardiothoracic Surgery

MD Van Kerkhove, Julie Parsonnet, M Weingart, LS Tompkins
Infectious Control and Hospital Epidemiology , 2006

Six cases of coagulase-negative staphylococcal mediastinitis were identified in the latter half of 1999. A new preoperative cleansing solution was suspected by hospital staff to be a factor in the outbreak. We evaluated this possible risk factor along with other known and suspected surgical site infection risk factors in this case-control study.

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Journal Articles

Validation of the Blood Quininium Resin Test for Assessing Gastric Hypochlorhydria

C de Martel, S Ratanasopa, D Passaro, Julie Parsonnet
Digestive Diseases and Sciences , 2006

Although gastric hypochlorhydria is a risk factor for gastroenteritis and for gastric cancer, no reliable, inexpensive, noninvasive test exists for screening or epidemiologic studies. We aimed to evaluate the sensitivity and specificity of the blood quininium resin test (bQRT) for hypochlorhydria, against pH monitoring. Twelve fasting adult volunteers-seven with and five without H. pylori infection-ingested 80 mg/kg of quininium resin twice, once with and once without acid suppression. Gastric pH was monitored for 75 minutes; serum samples were obtained at times 0 and 75 minutes.

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Journal Articles

Acquisition of Helicobacter Pylori Infection in Rhesus Macaques is Most Consistent with Oral-Oral Transmission

JV Solnick, J Fong, LM Hansen, K Chang, DR Canfield, Julie Parsonnet
Journal of Clinical Microbiology , 2006

Socially housed rhesus monkeys rapidly acquired Helicobacter pylori infection, although the organism was rarely cultivated from saliva, feces, or the environment. Since the concentrations of H. pylori in vomit were compatible with what is known about the infectious dose, our results are most consistent with an oral-oral means of transmission.

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Journal Articles

Helicobacter Pylori Infection and Gender: A Meta-Analysis of Population-Based Prevalence Surveys

C de Martel, Julie Parsonnet
Digestive Diseases and Sciences , 2006

Although most of Helicobacter pylori-related diseases are associated with male gender, the role of gender as a risk factor for H. pylori infection is still debated. To assess the true association between H. pylori and gender, we conducted a meta-analysis of large, population-based studies where the measure of association had been adjusted at least for age and socioeconomic status, and obtained primary data from authors when information on gender associations were not presented.

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Journal Articles

QuantiFERON-TB Predicts Tuberculin Skin Test Boosting in U.S. Foreign-Born

M Nguyen, S Perry, Julie Parsonnet
International Journal of Tuberculosis & Lung Disease , 2005

Setting: Santa Clara County, Northern California.

Objective: To characterize agreement of tuberculin skin test (TST) and QuantiFERON-TB (QFT) with repeated testing.

Design: Fifty-two subjects participating in an ongoing prospective study of infectious disease transmission were tested by TST and QFT at two home visits 3 months apart. Boosting was defined as reclassification of TST from negative to positive. Agreement and reproducibility of TST and QFT were assessed using kappa and McNemar statistics.

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Journal Articles

Risk of Intestinal Helminth and Protozoan Infection in a Refugee Population

PK Garg, S Perry, M Dorn, L Hardcastle, Julie Parsonnet
American Journal of Tropical Medicine and Hygiene , 2005

With continuing emigration from endemic countries, screening for parasitic infections remains a priority in U.S. communities serving refugee and immigrant populations. We report the prevalence of helminths and protozoa as well as demographic risk factors associated with these infections among 533 refugees seen at the Santa Clara County, California, Refugee Clinic between October 2001 and January 2004. Stool parasites were identified from 14% of refugees, including 9% found to have one or more protozoa and 6% found to have at least one helminth.

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Journal Articles

Significance of Transiently Positive Enzyme-Linked Immunosorbent Assay Results in Detection of Helicobacter pylori in Stool Samples from Children

TD Haggerty, S Perry, L Sanchez, G Perez-Perez, Julie Parsonnet
Journal of Clinical Microbiology , 2005

In young children, the significance of stool samples transiently positive for Helicobacter pylori antigen is unknown. As part of a larger prospective study on enteric infections, stool samples were obtained from 323 children at two time points 3 months apart and tested for H. pylori antigen using a commercially available enzyme-linked immunosorbent assay (ELISA) test.

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Journal Articles

Helicobacter pylori Infection in Different Generations of Hispanics in the San Francisco Bay Area

CJ Tsai, S Perry, L Sanchez, Julie Parsonnet
American Journal of Epidemiology , 2005

To quantify the contributions of household and environmental factors to Helicobacter pylori infection, the authors examined H. pylori infection among several generations of Hispanics in the San Francisco Bay Area.

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Journal Articles

Helicobacter Pylori Infection and the Risk of Development of Esophageal Adenocarcinoma

C de Martel, AE Llosa, SM Farr, GD Friedman, JH Vogelman, N Orentreich, DA Corley, Julie Parsonnet
Journal of Infectious Diseases , 2005

Background: An increase in the incidence of esophageal adenocarcinoma has coincided with a decrease in the prevalence of Helicobacter pylori infection. Whether these 2 phenomena are associated is unknown.

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Journal Articles

Helicobacter pylori Eradication and Gastric Preneoplastic Conditions: A Randomized, Double-Blind, Placebo-Controlled Trial

C Ley, A Mohar, J Guarner, R Herrera-Goepfert, LS Figueroa, D Halperin, I Johnstone, Julie Parsonnet
Cancer Epidemiology Biomarkers & Prevention , 2004
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Journal Articles

Helicobacter pylori and Risk of Gastroenteritis.

S Perry, L Sanchez, S Yang, TD Haggerty, P Hurst, Julie Parsonnet
Journal of Infectious Diseases , 2004

Background: Helicobacter pylori infection is thought to modify susceptibility to gastroenteritis.

Methods: Members of northern California households with an index case of gastroenteritis were interviewed regarding recent episodes and tested for H. pylori. Conditional logistic regression was used to evaluate the risk of secondary gastroenteritis within households matched for members with secondary gastroenteritis (cases) and those without symptoms (control subjects). Case and control subjects were also tested for hepatitis A virus (HAV).

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Journal Articles

C-Reactive Protein, Helicobacter pylori, Chlamydia Pneumoniae, Cytomegalovirus and Risk for Myocardial Infarction

HL Witherell, KL Smith, GD Friedman, C Ley, DH Thom, N Orentreich, JH Vogelman, Julie Parsonnet
Annals of Epidemiology , 2003

Purpose: C-reactive protein (CRP), Chlamydia pneumonia, Helicobacter pylori, and cytomegalovirus (CMV) have each been associated with atherosclerosis. We assessed how infection and CRP related to risk for subsequent myocardial infarction (MI).

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Journal Articles

No Association Between Helicobacter pylori and Mycobacterium Tuberculosis Infections Among Gastrointestinal Clinic Attendees in Lima, Peru

MA Torres, DJ Passaro, J Watanabe, Julie Parsonnet, P Small, J Miyagu, C Rodriquez, M Astete, RH Gilman
Epidemiology and Infection , 2003

Helicobacter pylori (HP) infection can cause hypochlorhydria, a positive risk factor for Mycobacterium tuberculosis (MTB) infection. This study examined the association between HP and MTB infections among persons attending the Policlinico Peruano Japones Gastrointestinal Clinic in Lima, Peru. From 23 June 2000 to 18 August 2000, consenting 18-55 year olds who attended the clinic for gastric biopsy gave blood for HP serologic testing, underwent tuberculin skin testing (TST) and completed a social and medical history.

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Journal Articles

Variability in Antibiotic Prescribing Patterns and Outcomes in Patients with Clinically Suspected Ventilator-Associated Pneumonia

RA Fowler, K Flavin, J Barr, AB Weinacker, Julie Parsonnet, Michael K. Gould
Chest , 2003

Study Objectives: To describe the variation in clinical practice strategies for the treatment of suspected ventilator-associated pneumonia (VAP) in a population of critically ill patients, and to determine whether initial empiric treatment with certain antibiotics, monotherapy vs combination antibiotic therapy, or appropriate vs inappropriate antibiotic therapy is associated with survival, length of hospital stay, or days free of antibiotics.

Design: Prospective, observational cohort study.

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Journal Articles

What is the Helicobacter pylori Global Reinfection Rate?

Julie Parsonnet
Canadian Journal of Gastroenterology , 2003

Reinfection with any organism is related to the force of infection in the population and on both innate and acquired immunity to infection. Little is yet known about primary immune protection against Helicobacter pylori. Some data suggest that children can be recurrently infected, spontaneously eliminating the organism only to be infected again and again until the organism takes hold. This pattern of recurrent infection is not observed in patients who receive eradication therapy for chronic infection.

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Journal Articles

Helicobacter pylori in Cathartic Stools of Subjects With and Without Cimetidine-Induced Hypochlorhydria

T Haggerty, H Shmuely, Julie Parsonnet
Journal of Medical Microbiology , 2003

We previously identified viable Helicobacter pylori in stools from asymptomatic hosts. We now report whether a decrease in gastric acidity enhances faecal shedding. Sixteen asymptomatic H. pylori-positive patients underwent two separate days of phosphosoda-induced diarrhoea, both with normal gastric acidity and under hypochlorhydric conditions induced with the H2-blocker cimetidine. Stool samples were collected for culture to determine the presence of viable H. pylori.

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Journal Articles

A Modification of the Quininium Resin Test for Assessing Gastric Acidity

DJ Passaro, A Hurwitz, G Triadafilopoulos, Julie Parsonnet
Alimentary Pharmacology & Therapeautics , 2002

Background: Gastric acid is an important defence against enteric infection. Studies investigating the relationship between hypochlorhydria and enteric infections or gastric malignancy have been limited by difficulties in the non-invasive measurement of gastric acidity. AIM: To develop a blood test for hypochlorhydria based on the quininium resin test.

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Journal Articles

Growth Slowing After Acute Helicobacter pylori Infection is Age-Dependent

DJ Passaro, DN Taylor, RH Gilman, L Cabrera, Julie Parsonnet
Journal of Pediatric Gastroenterology , 2002

Objective: Most infections occur during childhood, but the health effects of childhood infection are poorly understood. We investigated whether growth decreases in the 2 months after acute seroconversion.

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Journal Articles

CagA Status of Helicobacter pylori Infection and p53 Gene Mutations in Gastric Adenocarcinoma

A Shibata, Julie Parsonnet, TA Longacre, MI Garcia, B Puligandla, RE Davis, JH Vogelman, N Orentreich, LA Habel
Carcinogenesis , 2002
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Journal Articles

C-Reactive Protein, Helicobacter pylori, Chlamydia pneumonia, Cytomegalovirus and Risk for Myocardial Infarction: A Prospective Study

HL Witherell, KL Smith, GD Friedman, C Ley, DH Thom, N Orentreich, JH Vogelman, Julie Parsonnet
Annals of Epidemiology , 2002
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Journal Articles

Validation of a Spanish Language Dyspepsia Questionnaire

JA Goldman, D Conrad, CL Ley, D Halperin, ML Sanchez, R Villacorta, Julie Parsonnet
Dig Dis Sci , 2002
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Journal Articles

Eradication Rate of Helicobacter pylori in a Mexican Population at High Risk for Gastric Cancer and Use of Serology to Assess Cure

A Mohar, C Ley, J Guarner, R Herrera-Goepfert, L Sanchez Figueroa, D Halperin, Julie Parsonnet
American Journal of Gastroenterology , 2002
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Journal Articles

Histological Classification of Gastric Adenocarcinoma for Epidemiological Research: Concordance Between Pathologists

A Shibata, TA Longacre, B Puligandla, Julie Parsonnet, LA Habel
Cancer Epidemiology Biomarkers & Prevention , 2001

Epidemiology of gastric adenocarcinoma suggests that intestinal-type and diffuse-type cancers develop through distinct causal pathways. To examine the differences in risk factors and molecular changes between the histological types, reliable data on histological typing are essential. We evaluated the concordance between two pathologists in assessment of 95 gastric adenocarcinomas for Lauren classification and tumor grade. Two pathologists, each blinded to the other's assessment, reviewed H&E-stained slides of gastric tumor.

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Journal Articles

Screening Markers for Chronic Atrophic Gastritis in Chiapas, Mexico

C Ley, A Mohar, J Guarner, R Herrera-Goepfert, LS Figueroa, D Halperin, Julie Parsonnet
Cancer Epidemiology Biomarkers & Prevention , 2001

Intestinal-type gastric adenocarcinomas usually are preceded by chronic atrophic gastritis. Studies of gastric cancer prevention often rely on identification of this condition. In a clinical trial, we sought to determine the best serological screening method for chronic atrophic gastritis and compared our findings to the published literature. Test characteristics of potential screening tests (antibodies to Helicobacter pyloni or CagA, elevated gastrin, low pepsinogen, increased age) alone or in combination were examined among consecutive subjects enrolled in a study of H.

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