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Glenn M. Chertow
Journal Articles

Fetuin-A and Change in Body Composition in Older Persons

Ix JH, Wassel CL, Glenn M. Chertow, Koster A, Johnson KC, Tylavsky FA, Cauley JA, Cummings SR, Harris TB Harris TB, Shilpak MG Shilpak MG
Journal of Clinical Endocrinology and Metabolism , 2009

Context: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown.

Objective: To determine the association of fetuin-A levels with changes in body composition over 5 yr.

Study Design: Observational cohort study nested in the Health Aging and Body Composition Study.

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Journal Articles

Increased fluid intake does not augment capacity to lay down new collagen in nursing home residents at risk for pressure ulcers: A randomized, controlled clinical trial.

Stotts NA, Hopf HW, Kayser-Jones J, Glenn Chertow, Cooper BA, Wu HS
Wound, Repair and Regeneration , 2009

Prevention of pressure ulcers is fundamental to safe care of nursing home residents yet the role of hydration in pressure ulcer prevention has not been systematically examined. This randomized clinical trial was undertaken to determine whether administration of supplemental fluid to nursing home residents at risk for pressure ulcers would enhance collagen deposition, increase estimated total body water, augment subcutaneous tissue oxygenation, and was safe.

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Journal Articles

Dialysis: Phosphorus Binders and Survival: Need for Randomized Trials.

Ix JH, Glenn Chertow
Nature Reviews Nephrology , 2009

An observational study suggests that administration of phosphorus binders dramatically improves survival rates in patients on incident hemodialysis-even in those without hyperphosphatemia. Randomized clinical trials should drive changes in the relevant clinical practice.

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Journal Articles

Is There Cherry Picking in the ESRD Program? Perceptions from a National Provider Survey

Amar Desai, Bolus R, Nissenson A, Glenn M. Chertow, Bolus S, Solomon MD, Khawar OS, Talley J, Spiegel BM
Clinical Journal of the American Society of Nephrology , 2009

Background and objectives: Changes in ESRD reimbursement policy, including proposed bundled payment, have raised concern that dialysis facilities may use "cherry picking" practices to attract a healthier, better insured, or more adherent patient population.

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Journal Articles

Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury

Palevsky PM, Zhang JH, O'Connor TZ, Glenn M. Chertow, Crowley ST, Choudury D, Finkel K, Kellum JA, Paganini E, Schein RMH, Smith MW, Swanson KM, Vijayan A, Watnick S, Star RA, Peduzzi P
N Engl J Med , 2008

BACKGROUND: The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial.

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Journal Articles

Management of acute kidney injury in the intensive care unit: a cost-effectiveness analysis of daily vs alternate-day hemodialysis.

Amar Desai, Baras J, Berk B, Nakajima A, Alan M. Garber, Douglas K. Owens, Glenn Chertow
Archives of Internal Medicine , 2008

BACKGROUND: Although evidence suggests that a higher hemodialysis dose and/or frequency may be associated with improved outcomes, the cost-effectiveness of a daily hemodialysis strategy for critically ill patients with acute kidney injury (AKI) is unknown. METHODS: We developed a Markov model of the cost, quality of life, survival, and incremental cost-effectiveness of daily hemodialysis, compared with alternate-day hemodialysis, for patients with AKI in the intensive care unit (ICU). We employed a societal perspective with a lifetime analytic

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Journal Articles

Intensity of Renal Support for Acute Kidney Injury in the Critically Ill

Palevsky PP, Zhang JH, O'Connor TZ, Glenn M. Chertow, Crowley S, Choudhury D, Finkel K, Kellum JA, Paganini E, Schein RMH, Mark W. Smith, Swanson K, Thompson BT, Vijayan A, Watnick S, Star RA, Peduzzi P
New England Journal of Medicine , 2008

Background
The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial.

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Journal Articles

Race and Mortality after Acute Renal Failure

Waikar SS, Curhan GC, Ayanian JZ, Glenn M. Chertow
J Am Soc Nephrol , 2007

Black patients receiving dialysis for end-stage renal disease in the United States have lower mortality rates than white patients. Whether racial differences exist in mortality after acute renal failure is not known. We studied acute renal failure in patients hospitalized between 2000 and 2003 using the Nationwide Inpatient Sample and found that black patients had an 18% (95% confidence interval [CI] 16 to 21%) lower odds of death than white patients after adjusting for age, sex, comorbidity, and the need for mechanical ventilation.

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Journal Articles

Octogenarians and Nonagenarians Starting Dialysis in the United States

Kurella M, Covinksy KE, Collins AJ, Glenn Chertow
Ann Intern Med , 2007

BACKGROUND: The elderly constitute the fastest-growing segment of the end-stage renal disease (ESRD) population, but the epidemiology and outcomes of dialysis among the very elderly, that is, those 80 years of age and older, have not been previously examined at a national level. OBJECTIVE: To describe recent trends in the incidence and outcomes of octogenarians and nonagenarians starting dialysis. DESIGN: Observational study. SETTING: U.S. Renal Data System, a comprehensive, national registry of patients with ESRD.

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Journal Articles

Declining Mortality in Patients with Acute Renal Failure, 1988-2002

Waikar SS, Curhan GC, Wald R, McCarthy EP, Glenn Chertow
J Am Soc Nephrol , 2006
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Journal Articles

Chronic Kidney Disease and Risk of Death, Cardiovascular Events and Hospitalization

Go AS, Glenn M. Chertow, Fan D, McCulloch CE, Hsu CY
N Engl J Med , 2004
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Journal Articles

Management of acute kidney injury in the intensive care unit: a cost-effectiveness analysis of daily vs alternate-day hemodialysis

Amar Desai, Baras J, Berk BB, Nakajima A, Alan M. Garber, Douglas K. Owens, Glenn M. Chertow
Arch Intern Med , 2000

BACKGROUND: Although evidence suggests that a higher hemodialysis dose and/or frequency may be associated with improved outcomes, the cost-effectiveness of a daily hemodialysis strategy for critically ill patients with acute kidney injury (AKI) is unknown. METHODS: We developed a Markov model of the cost, quality of life, survival, and incremental cost-effectiveness of daily hemodialysis, compared with alternate-day hemodialysis, for patients with AKI in the intensive care unit (ICU). We employed a societal perspective with a lifetime analytic time horizon.

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