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Dena M. Bravata
Journal Articles

Are organic foods safer or healthier than conventional alternatives? A systematic review.

Crystal Smith-Spangler, Margaret L. Brandeau, Hunter, G.E., Clay Bavinger, Pearson, M., Eschbach, P.J., Vandana Sundaram, Hau Liu, Schirmer, P., Stave, C., Ingram Olkin, Dena M. Bravata
Annals of Internal Medicine , 2012
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Journal Articles

Cost Effectiveness of Elective Induction of Labor at 41 Weeks in Nulliparous Women

Aaron B Caughey, Vandana Sundaram, Anjali J Kaimal, Yvonne W. Cheng, Allison Gienger, Sarah E Little, Jason Lee, Luchin Wong, Brian L Shaffer, Susan H Tran, Amy Padula, Kathryn M. McDonald, Elisa F Long, Douglas Owens, Dena Bravata
American Journal Of Obstetrics Gynecology , 2011

BACKGROUND: Induction of labor is on the rise in the U.S., increasing from 9.5 percent in 1990 to 22.1 percent in 2004. Although, it is not entirely clear what proportion of these inductions are elective (i.e. without a medical indication), the overall rate of induction of labor is rising faster than the rate of pregnancy complications that would lead to a medically indicated induction. However, the maternal and neonatal effects of induction of labor are unclear. Many studies compare women with induction of labor to those in spontaneous labor.

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Journal Articles

Systematic Review: Benefits and Harms of In-Hospital Use of Recombinant Factor VIIa for Off-Label Indications

Veronica Yank, C. Vaughan Tuohy, Aaron C Logan, Dena M. Bravata, Kristan Staudenmayer, Robin Eisenhut, Vandana Sundaram, Donal McMahon, Ingram Olkin, Kathryn M. McDonald, Douglas K. Owens, Randall S. Stafford
Annals of Internal Medicine , 2011

Background:Recombinant factor VIIa (rFVIIa), a hemostatic agent approved for hemophilia, is increasingly used for off-label indications.

Purpose:To evaluate the benefits and harms of rFVIIa use for 5 off-label, in-hospital indications: intracranial hemorrhage, cardiac surgery, trauma, liver transplantation, and prostatectomy.

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Journal Articles

Diagnosing and Managing Common Food Allergies

Jennifer Schneider, Newberry SJ, Riedl MA, Dena M. Bravata, Maglione M, Suttorp MJ, Vandana Sundaram, Paige NM, Towfigh A, Hulley BJ, Shekelle PG
Journal of the American Medical Association , 2010

Context There is heightened interest in food allergies but no clear consensus exists regarding the prevalence or most effective diagnostic and management approaches to food allergies.

Objective To perform a systematic review of the available evidence on the prevalence, diagnosis, management, and prevention of food allergies.

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Journal Articles

Comparative Effectiveness of Recombinant Factor VIIa for Off-label Indications Versus Usual Care

V Yank, V Tuohy, AC Logan, Dena M. Bravata, K Staudenmayer, Vandana Sundaram, D McMahon, CD Stave, JL Zehnder, I Olkin, Kathryn M. McDonald, Douglas K. Owens, Randall Stafford Randall Stafford
Comparative Effectiveness , 2010

This report evaluates the level of evidence currently available to support the effectiveness and safety of using recombinant activated coagulation factor VII (rFVIIa) for clinical indications not approved by the U. S. Food and Drug Administration (FDA). rFVIIa is approved for a variety of uses in hemophilia patients who have developed antibody inhibitors that compromise the use of standard factor replacement. Use of this costly biologic product has expanded beyond these hemophilia-related indications to encompass a range of off-label uses, most of which are in-hospital uses.

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Journal Articles

CABG versus PCI for multivessel coronary artery disease - authors' reply

Mark A. Hlatky, Dena M. Bravata, Kathryn M. McDonald, Douglas Owens
The Lancet , 2009
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Journal Articles

Quality improvement strategies for children with asthma: A systematic review

Dena M. Bravata, Gienger AL, Jon-Erik Holty, Vandana Sundaram, Nayer Khazeni, Paul H. Wise, Kathryn McDonald, Douglas Owens
Pediatrics and Adolescent Medicine , 2009

Abstract

OBJECTIVE:

To evaluate the evidence that quality improvement (QI) strategies can improve the processes and outcomes of outpatient pediatric asthma care.

DATA SOURCES:

Cochrane Effective Practice and Organisation of Care Group database (January 1966 to April 2006), MEDLINE (January 1966 to April 2006), Cochrane Consumers and Communication Group database (January 1966 to May 2006), and bibliographies of retrieved articles.

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Journal Articles

Safety and Efficacy of Extended-Duration Antiviral Chemoprophylaxis Against Pandemic and Seasonal Influenza

Nayer Khazeni, Dena M. Bravata, Jon-Erik Holty, Uyeki TM, Stave CD, Michael K. Gould
Annals of Internal Medicine , 2009

Background: Neuraminidase inhibitors (NAIs) are stockpiled internationally for extended use in an influenza pandemic.

Purpose: To evaluate the safety and efficacy of extended-duration (>4 weeks) NAI chemoprophylaxis against influenza.

Data Sources: Studies published in any language through 11 June 2009 identified by searching 10 electronic databases and 3 trial registries.

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Journal Articles

Systematic Review: Elective Induction of Labor Versus Expectant Management of Pregnancy

Caughey AB, Vandana Sundaram, Kaimal AJ, Allison Gienger, Cheng YW, Kathryn M. McDonald, Shaffer BL, Douglas Owens, Dena Bravata
Annals of Internal Medicine , 2009

Background: The rates of induction of labor and elective induction of labor are increasing. Whether elective induction of labor improves outcomes or simply leads to greater complications and health care costs is commonly debated in the literature.

Purpose: To compare the benefits and harms of elective induction of labor and expectant management of pregnancy.

Data Sources: MEDLINE (through February 2009), Web of Science, CINAHL, Cochrane Central Register of Controlled Trials (through March 2009), bibliographies of included studies, and previous systematic reviews.

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Journal Articles

Evaluating the Surgery Literature: Can Standardizing Peer-review Today Predict Manuscript Impact Tomorrow?

Sosa JA, Metha P, Thomas DC, Berland G, Gross C, McNamara RL, Rosenthal R, Udelsman R, Dena M. Bravata, Roman SA
Annals of Surgery , 2009

OBJECTIVE: Evidence-based surgery is predicated on the quality of published literature. We measured the quality of surgery manuscripts selected by peer review and identified predictors of excellence.

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Policy Briefs

Recommendations for Modeling Disaster Responses in Public Health and Medicine: A Position Paper of the Society for Medical Decision Making

Margaret L. Brandeau, McCoy JH, Hupert H, Jon-Erik Holty, Dena Bravata
Medical Decision Making , 2009

Purpose. Mathematical and simulation models are increasingly used to plan for and evaluate health sector responses to disasters, yet no clear consensus exists regarding best practices for the design, conduct, and reporting of such models. The authors examined a large selection of published health sector disaster response models to generate a set of best practice guidelines for such models.

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Journal Articles

Quality Improvement Strategies for Children With Asthma

Dena M. Bravata, Allison Gienger, Jon-Erik Holty, Vandana Sundaram, Nayer Khazeni, Paul H. Wise, Kathryn McDonald, Douglas Owens
Archives of Pediatrics and Adolescent Medicine , 2009

Objective To evaluate the evidence that quality improvement (QI) strategies can improve the processes and outcomes of outpatient pediatric asthma care.

Data Sources Cochrane Effective Practice and Organisation of Care Group database (January 1966 to April 2006), MEDLINE (January 1966 to April 2006), Cochrane Consumers and Communication Group database (January 1966 to May 2006), and bibliographies of retrieved articles.

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Journal Articles

Coronary Artery Bypass Surgery Compared with Percutaneous Coronary Interventions for Multivessel Disease: A Collaborative Analysis of Individual Patient Data from Ten Randomised Trials

Mark A. Hlatky, Boothroyd DB, Dena M. Bravata, Boersma E, Booth J, Brooks MM, Carrie MD, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kahler J, Kelsey SF, King SB, Kosinski AS, Lopes N, Kathryn M. McDonald, Rodriguez A, Serruys P, Sigwart P, Stables RH, Douglas K. Owens, Pocock SJ
The Lancet , 2009

Background

Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease. Although the procedures have been compared in several randomised trials, their long-term effects on mortality in key clinical subgroups are uncertain. We undertook a collaborative analysis of data from randomised trials to assess whether the effects of the procedures on mortality are modified by patient characteristics.

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Policy Briefs

Maternal and Neonatal Outcomes of Elective Induction of Labor

Caughey AB, Vandana Sundaram, Kaimal AJ, Cheng YW, Allison Gienger, Little SE, Lee JF Lee JF, Shaffer BL Shaffer BL , Tran SH, Padula A, Kathryn M. McDonald, Long EF, Douglas Owens, Dena Bravata
Evidence report/technology assessment , 2009

Background: Induction of labor is on the rise in the U.S., increasing from 9.5 percent in 1990 to 22.1 percent in 2004. Although, it is not entirely clear what proportion of these inductions are elective (i.e. without a medical indication), the overall rate of induction of labor is rising faster than the rate of pregnancy complications that would lead to a medically indicated induction. However, the maternal and neonatal effects of induction of labor are unclear. Many studies compare women with induction of labor to those in spontaneous labor.

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Journal Articles

Decision Framework for Coordinating Bioterrorism Planning, A: Lessons from the BioNet Program

Manley DK, Dena M. Bravata,
American Journal of Disaster Medicine , 2009

Background: Effective disaster preparedness requires coordination across multiple organizations. This article describes a detailed framework developed through the BioNet program to facilitate coordination of bioterrorism preparedness planning among military and civilian decision makers.

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Journal Articles

Isolated disease of the proximal left anterior descending artery. comparing the effectiveness of percutaneous coronary interventions and coronary artery bypass surgery

John R. Kapoor, Allison L. Gienger, Reza Ardehali, Robin Varghese, Marco V. Perez, Vandana Sundaram, Kathryn M. McDonald, Douglas K. Owens, Mark A. Hlatky, Dena Bravata
JACC: Cardiovascular Interventions , 2008

Objectives: This study sought to systematically compare the effectiveness of percutaneous coronary intervention and coronary artery bypass surgery in patients with single-vessel disease of the proximal left anterior descending (LAD) coronary artery.

Background: It is uncertain whether percutaneous coronary interventions (PCI) or coronary artery bypass grafting (CABG) surgery provides better clinical outcomes among patients with single-vessel disease of the proximal LAD.

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Journal Articles

Simple counts of ADL dependencies do not adequately reflect older adults' preferences toward states of functional impairment.

Tamara L. Sims, Holmes TH, Dena M. Bravata, Alan Garber, Lorene Nelson, Mary Goldstein
Journal of Clinical Epidemiology , 2008

OBJECTIVE: To use unweighted counts of dependencies in activities of daily living (ADLs) to assess the impact of functional impairment requires an assumption of equal preferences for each ADL dependency. To test this assumption, we analyzed standard gamble (SG) utilities of single and combination ADL dependencies among older adults. STUDY DESIGN AND SETTING: Four hundred older adults used multimedia software (FLAIR1) to report SG utilities for their current health and hypothetical health states of dependency in each of 7 ADLs and 8 of 30

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Journal Articles

Modeling the Logistics of Response to Anthrax Bioterrorism

GS Zaric, Dena M. Bravata, Jon-Erik Holty, Kathryn M. McDonald, Douglas K. Owens, Margaret L. Brandeau
Medical Decision Making , 2008

Background: A bioterrorism attack with an agent such as anthrax will require rapid deployment of medical and pharmaceutical supplies to exposed individuals. How should such a logistical system be organized? How much capacity should be built into each element of the bioterrorism response supply chain?

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Journal Articles

Systematic Review: The Effects of Growth Hormone on Athletic Performance

Hau Liu, Dena M. Bravata, Ingram Olkin, Roberts B, Eran Bendavid, Olga Saynina, Salpeter SR, Alan Garber, Hoffman AR
Annals of Internal Medicine , 2008

BACKGROUND: Human growth hormone is reportedly used to enhance athletic performance, although its safety and efficacy for this purpose are poorly understood. PURPOSE: To evaluate evidence about the effects of growth hormone on athletic performance in physically fit, young individuals.

DATA SOURCES: MEDLINE, EMBASE, SPORTDiscus, and Cochrane Collaboration databases were searched for English-language studies published between January 1966 and October 2007.

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Journal Articles

An Ounce of Prevention Is Worth a Pound of Cure: Improving Communication to Reduce Mortality During Bioterrorism Responses

Margaret L. Brandeau, Zaric, G.S., Freiesleben, J. Freiesleben, J., Edwards, F.L. Edwards, F.L., Dena M. Bravata
American Journal of Disaster Medicine , 2008

OBJECTIVE: To identify communication needs and evaluate the effectiveness of alternative communication strategies for bioterrorism responses. METHODS: We provide a framework for evaluating communication needs during a bioterrorism response. Then, using a simulation model of a hypothetical response to anthrax bioterrorism in a large metropolitan area, we evaluate the costs and benefits of alternative strategies for communication during a response.

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Journal Articles

Using Pedometers to Increase Physical Activity and Improve Health: A Systematic Review

Dena M. Bravata, C Smith-Spangler, Vandana Sundaram, Allison Gienger, Nancy D. Lin, Robyn Lewis, CD Stave, Ingram Olkin, JR Sirard
Journal of the American Medical Association , 2007

Context: Without detailed evidence of their effectiveness, pedometers have recently become popular as a tool for motivating physical activity.

Objective: To evaluate the association of pedometer use with physical activity and health outcomes among outpatient adults.

Data Sources: English-language articles from MEDLINE, EMBASE, Sport Discus, PsychINFO, Cochrane Library, Thompson Scientific (formerly known as Thompson ISI), and ERIC (1966-2007); bibliographies of retrieved articles; and conference proceedings.

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Journal Articles

Systematic Review: The Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Graft Surgery

Dena M. Bravata, Allison Gienger, Kathryn M. McDonald, Vandana Sundaram, MV Perez, R Varghese, JR Kapoor, R Ardehali, Douglas K. Owens, Mark A. Hlatky
Annals of Internal Medicine , 2007

Background: The comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) for patients in whom both procedures are feasible remains poorly understood.

Purpose: To compare the effectiveness of PCI and CABG in patients for whom coronary revascularization is clinically indicated.

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Journal Articles

Rosiglitazone Increased Heart failure But Did Not Differ from Metformin Plus Sulfonylurea for Other CV Outcomes at Interim Analysis

Mark A. Hlatky, Dena M. Bravata
American College of Physicians Journal Club , 2007
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Journal Articles

CoPlot: A Tool for Visualizing Multivariate Data in Medicine

Dena M. Bravata, KG Shojania, Ingram Olkin, A Raveh
Statistics in Medicine , 2007

Many critical questions in medicine require the analysis of complex multivariate data, often from large data sets describing numerous variables for numerous subjects. In this paper, we describe CoPlot, a tool for visualizing multivariate data in medicine. CoPlot is an adaptation of multidimensional scaling (MDS) that addresses several key limitations of MDS, namely that MDS maps do not allow for visualization of both observations and variables simultaneously and that the axes on an MDS map have no inherent meaning.

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Journal Articles

Systematic Review: The Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Surgery

Dena M. Bravata, Allison Gienger, Kathryn M. McDonald, Vandana Sundaram, MV Perez, R Varghese, JR Kapoor, R Ardehali, Douglas K. Owens, Mark A. Hlatky
Annals of Internal Medicine , 2007

Background: The comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) for patients in whom both procedures are feasible remains poorly understood.

Purpose: To compare the effectiveness of PCI and CABG in patients for whom coronary revascularization is clinically indicated.

Data Sources: MEDLINE, EMBASE, and Cochrane databases (1966-2006); conference proceedings; and bibliographies of retrieved articles.

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